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Nature, the worlds most prestigious science journal, and ENCODE the Encyclopedia of DNA Elements, commissioned us to create an iconic image for their official release of the latest human genome map. This was a wonderful challenge because Nature expressed the need for a graphic that spoke to the large quantities of data and science behind the project but didn't want an image that was mired in technical detail. Even more, it was equally important that the final image have a strong sense of humanity and not be purely an abstract statement. With all this in mind we started by examining the actual report released by ENCODE. We then distilled a technical visualization down to a simple graphic statement. The graphic to the right, as seen on the cover, is constructed of 22 segments, one for each human chromosome, plus a 23rd segment for the X, Y or sex chromosomes. This visual distillation of the actual science was then designed into the form of a human iris, which was an accurate analogy for the what ENCODE is searching for. Ultimately we developed a visual that pays homage to the data and science behind the project while hopefully capturing a bit of the wonder of what this endeavor hopes to achieve.